REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features
Identifieur interne : 002384 ( Main/Exploration ); précédent : 002383; suivant : 002385REM sleep behaviour disorder in Parkinson's disease is associated with specific motor features
Auteurs : R. B. Posturna [Canada] ; J. F. Gagnon [Canada] ; M. Vendette [Canada] ; K. Charland [Canada] ; J. Montplaisir [Canada]Source :
- Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background: Rapid eye movement (REM) sleep behaviour disorder (RBD) is commonly associated with Parkinson's disease (PD), and recent studies have suggested that RBD in PD is associated with increased cognitive impairment, waking EEG slowing, autonomic impairment and lower quality of life on mental health components. However, it is unclear whether the association of RBD in PD has implications for motor manifestations of the disease. Methods: The study evaluated 36 patients with PD for the presence of RBD by polysomnography. Patients underwent an extensive evaluation on and off medication by a movement disorders specialist blinded to the polysomnography results. Measures of disease severity, quantitative motor indices, motor subtypes, complications of therapy and response to therapy were assessed and compared using regression analysis that adjusted for disease duration and age. Results: Patients with PD and RBD were less likely to be tremor predominant (14% vs 53%; p<0.02) and had a lower proportion of their Unified Parkinson Disease Rating Scale (UPDRS) score accounted for by tremor (8.2% vs 19.0%; p<0.01). An increased frequency of falls was noted among patients with RBD (38% vs 7%; p = 0.04). Patients with RBD demonstrated a lower amplitude response to their medication (UPDRS improvement 16.2% vs 34.8%; p = 0.049). Markers of overall disease severity, quantitative motor testing and motor complications did not differ between groups. Conclusions: The presence of altered motor subtypes in PD with RBD suggests that patients with PD and RBD may have a different underlying pattern of neurodegeneration than PD patients without RBD.
Affiliations:
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Posturna</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, McGill University, Montreal General Hospital</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'étude du sommeil, Hopital du Sacre-Coeur</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Québec</wicri:noRegion></affiliation></author><author><name sortKey="Gagnon, J F" sort="Gagnon, J F" uniqKey="Gagnon J" first="J. F." last="Gagnon">J. F. Gagnon</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'étude du sommeil, Hopital du Sacre-Coeur</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, Université de Montréal</s1><s2>Québec</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Vendette, M" sort="Vendette, M" uniqKey="Vendette M" first="M." last="Vendette">M. 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B." last="Posturna">R. B. Posturna</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Neurology, McGill University, Montreal General Hospital</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'étude du sommeil, Hopital du Sacre-Coeur</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Québec</wicri:noRegion></affiliation></author><author><name sortKey="Gagnon, J F" sort="Gagnon, J F" uniqKey="Gagnon J" first="J. F." last="Gagnon">J. F. Gagnon</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'étude du sommeil, Hopital du Sacre-Coeur</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, Université de Montréal</s1><s2>Québec</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Vendette, M" sort="Vendette, M" uniqKey="Vendette M" first="M." last="Vendette">M. Vendette</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'étude du sommeil, Hopital du Sacre-Coeur</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Québec</wicri:noRegion></affiliation></author><author><name sortKey="Charland, K" sort="Charland, K" uniqKey="Charland K" first="K." last="Charland">K. Charland</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Epidemiology and Biostatistics, McGill University</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Montplaisir, J" sort="Montplaisir, J" uniqKey="Montplaisir J" first="J." last="Montplaisir">J. Montplaisir</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Centre d'étude du sommeil, Hopital du Sacre-Coeur</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montréal, Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, Université de Montréal</s1><s2>Québec</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavioral disorder</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Rapid eye movement sleep</term><term>Sleep disorder</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term><term>Trouble du comportement</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Sommeil paradoxal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Rapid eye movement (REM) sleep behaviour disorder (RBD) is commonly associated with Parkinson's disease (PD), and recent studies have suggested that RBD in PD is associated with increased cognitive impairment, waking EEG slowing, autonomic impairment and lower quality of life on mental health components. However, it is unclear whether the association of RBD in PD has implications for motor manifestations of the disease. Methods: The study evaluated 36 patients with PD for the presence of RBD by polysomnography. Patients underwent an extensive evaluation on and off medication by a movement disorders specialist blinded to the polysomnography results. Measures of disease severity, quantitative motor indices, motor subtypes, complications of therapy and response to therapy were assessed and compared using regression analysis that adjusted for disease duration and age. Results: Patients with PD and RBD were less likely to be tremor predominant (14% vs 53%; p<0.02) and had a lower proportion of their Unified Parkinson Disease Rating Scale (UPDRS) score accounted for by tremor (8.2% vs 19.0%; p<0.01). An increased frequency of falls was noted among patients with RBD (38% vs 7%; p = 0.04). Patients with RBD demonstrated a lower amplitude response to their medication (UPDRS improvement 16.2% vs 34.8%; p = 0.049). Markers of overall disease severity, quantitative motor testing and motor complications did not differ between groups. Conclusions: The presence of altered motor subtypes in PD with RBD suggests that patients with PD and RBD may have a different underlying pattern of neurodegeneration than PD patients without RBD.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Posturna, R B" sort="Posturna, R B" uniqKey="Posturna R" first="R. B." last="Posturna">R. B. Posturna</name></region><name sortKey="Charland, K" sort="Charland, K" uniqKey="Charland K" first="K." last="Charland">K. Charland</name><name sortKey="Gagnon, J F" sort="Gagnon, J F" uniqKey="Gagnon J" first="J. F." last="Gagnon">J. F. Gagnon</name><name sortKey="Gagnon, J F" sort="Gagnon, J F" uniqKey="Gagnon J" first="J. F." last="Gagnon">J. F. Gagnon</name><name sortKey="Montplaisir, J" sort="Montplaisir, J" uniqKey="Montplaisir J" first="J." last="Montplaisir">J. Montplaisir</name><name sortKey="Montplaisir, J" sort="Montplaisir, J" uniqKey="Montplaisir J" first="J." last="Montplaisir">J. Montplaisir</name><name sortKey="Posturna, R B" sort="Posturna, R B" uniqKey="Posturna R" first="R. B." last="Posturna">R. B. Posturna</name><name sortKey="Vendette, M" sort="Vendette, M" uniqKey="Vendette M" first="M." last="Vendette">M. Vendette</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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